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首页> 外文OA文献 >Avidity of serogroup A meningococcal IgG antibodies after immunization with different doses of a tetravalent A/C/Y/W135 polysaccharide vaccine.
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Avidity of serogroup A meningococcal IgG antibodies after immunization with different doses of a tetravalent A/C/Y/W135 polysaccharide vaccine.

机译：用不同剂量的四价A / C / Y / W135多糖疫苗免疫后，血清群A脑膜炎球菌IgG抗体的亲和力。

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In the absence of an affordable conjugate meningococcal vaccine, mass vaccination campaigns with polysaccharide vaccines are the means to control meningitis epidemics in sub-Saharan Africa. Facing global vaccine shortage, the use of reduced doses, which have been shown to be protective by serum bactericidal activity, can save many lives. In this study, we investigated the antibody responses and avidity of IgG antibodies evoked against the serogroup A capsule of Neisseria meningitidis by different doses of an A/C/Y/W135 polysaccharide vaccine. Volunteers in Uganda were vaccinated with 1/10, 1/5 or a full dose (50 μg) and revaccinated with a full dose after 1 year. Specific IgG geometric mean concentrations and geometric mean avidity indices (GMAI) were determined by a modified enzyme-linked immunosorbent assay (ELISA) using thiocyanate as a chaotropic agent. After vaccination with 1/10 or 1/5 doses, the GMAI increased from 1 month to 1 year. One year following the initial dose, the GMAI levels were higher in the arm receiving reduced doses than for the arm receiving a full dose. Following the second full dose, avidity indices equalized at approximately the same level in the three arms. Although there are practical challenges to the use of reduced doses in the field, our findings suggest that reduced doses of polysaccharide vaccine are able to elicit antibodies of as good avidity against serogroup A polysaccharide as a full dose.
机译：在没有可负担得起的结合物脑膜炎球菌疫苗的情况下，使用多糖疫苗进行大规模疫苗接种是控制撒哈拉以南非洲流行的脑膜炎的手段。面对全球疫苗短缺，降低剂量的使用已被证明具有血清杀菌活性，可以拯救许多生命，减少剂量的使用已被证明具有血清杀菌作用。在这项研究中，我们调查了不同剂量的A / C / Y / W135多糖疫苗对脑​​膜炎奈瑟氏球菌A血清群诱发的IgG抗体反应和抗体的亲和力。乌干达的志愿者接种了1 / 10、1 / 5或全剂量（50μg）的疫苗，并在1年后用全剂量的疫苗接种。使用硫氰酸盐作为离液剂，通过改良的酶联免疫吸附测定（ELISA）确定特定IgG几何平均浓度和几何平均亲和力指数（GMAI）。接种1/10或1/5剂量的疫苗后，GMAI从1个月增加到1年。初始剂量后一年，接受减量剂量的手臂的GMAI水平高于接受全剂量手臂的GMAI水平。在第二次全剂量后，亲和力指数在三个组中大致相等。尽管在该领域中使用降低剂量存在实际挑战，但我们的发现表明，降低剂量的多糖疫苗能够引发与全剂量抗血清群A多糖一样好的抗体。

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